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DeepProfiler

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DeepProfiler uses deep neural networks to extract morphological features directly from raw microscopy images, bypassing traditional segmentation-and-measurement pipelines. It is designed for high-throughput screens where deep learning representations outperform classical feature sets.

Key capabilities:

  • Train and apply convolutional neural networks for feature extraction
  • Support for EfficientNet, ResNet, and custom architectures
  • Crop and embed single cells from large microscopy images
  • Produce embeddings compatible with pycytominer and downstream profiling workflows

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Publication #

Nature Communications · 2024

Learning representations for image-based profiling of perturbations

Moshkov N, Bornholdt M, Benoit G, Smith K, et al.

doi: 10.1038/s41467-024-45999-1